Utility of gated SPECT parameters in detection of coronary artery disease in patients with normal perfusion images

Abstract Background False negative myocardial perfusion images on single-photon emission computed tomography (SPECT) imaging (MPI) is a substantial problem in the interpretation of MPI. To explore possible parameters from gated SPECT that could detected coronary artery disease (CAD) patients with normal images, we retrospectively selected who underwent 2-day Tc-99 m MIBI adenosine stress/rest MPI and subsequent invasive angiography. Gated parameters, including end systolic volume (ESV), diastolic (EDV), left ventricular ejection fraction (LVEF), transient ischemic dilation (TID) ratio without CAD were compared assessed for their respective diagnostic performance using receiver operating characteristics (ROC) area under curve (AUC). Results Among 22 7 had CAD. Despite small number patients, found significant differences between ESV, EDV, LVEF The analysis ROC showed stress ESV excellently detect (AUC = 0.900). rest likewise perform well detection 0.833, 0.819, 0.790, 0.862, 0.838, respectively). In contrast, change TID 0.667 0.524, respectively) did not seem as reliable other parameters. Optimal cutoffs our study ≥ 20.0 mL 71.0 ≤ 66.3 EF units LVEF, 18.0 67.0 EDV 70.0 unit LVEF. Conclusions facilitate patient Tc-99m These should be carefully interpreted to improve accuracy reduce false